Test Code HIAAP 5-Hydroxyindoleacetic Acid, Plasma
Additional Codes
Epic EAP: LAB6278
Epic Description: 5HIAA PLASMA (NEUROENDOCRINE0
Ordering Guidance
This test quantifies 5-hydroxyindoleacetic acid in plasma specimens and is comparable to testing on 24-hour and random urine specimens for the diagnosis and monitoring of intestinal carcinoid syndrome.
Necessary Information
Patient's age is required.
Specimen Required
Patient Preparation:
1. Some medications could interfere with test results. If medically feasible, for 48 hours before and during specimen collection, patient should not take the following medications:
-Acetaminophen (Tylenol or generic versions)
-Tryptophan containing supplements.
2. For 24 hours prior to and during collection, the patient should limit the following to one serving per day:
-Fruits
-Vegetables
-Caffeinated beverages or foods
3. For 24 hours prior to and during collection, patients should not eat nuts, especially walnuts. Plasma 5-hydroxyindoleacetic acid levels revert to baseline levels when walnuts are ingested after other foods.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Green top (sodium heparin)
Acceptable: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Centrifuge at 4° C.
2. Aliquot plasma into plastic vial.
3. Send plasma frozen.
Specimen should be collected and transported on Ice. Centrifuge immediatedly and freeze aliquot.
Secondary ID
619735Useful For
Biochemical diagnosis and monitoring of intestinal carcinoid syndrome using a plasma specimen
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
5-Hydroxyindoleacetic Acid, PSpecimen Type
PlasmaSpecimen Minimum Volume
0.2 mL
Specimen Stability Information
Specimen Type | Temperature | Time |
---|---|---|
Plasma | Frozen (preferred) | 60 days |
Refrigerated | 72 hours |
Reject Due To
Gross hemolysis | OK |
Thawing** | Cold OK; Warm reject |
Gross lipemia | OK |
Gross icterus | OK |
Reference Values
≤6 months: ≤130 ng/mL
>6 months: ≤30 ng/mL
Day(s) Performed
Monday, Wednesday, Friday
Report Available
3 to 5 daysPerforming Laboratory

Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83497
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
HIAAP | 5-Hydroxyindoleacetic Acid, P | 1693-1 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
619735 | 5-Hydroxyindoleacetic Acid, P | 1693-1 |